(Senior) Research Technician Translational Development

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 150+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer® RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer® RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.

Our Translational Development department is seeking a versatile (Senior) Research Technician with bioanalytical expertise (full-time) to join our team in Leiden, the Netherlands. The Translational Development team operates collaboratively and conducts animal pharmacology, PK and safety studies, bioanalysis and biomarker assessment, in order to generate nonclinical data packages required to support the clinical development of ProQR’s Axiomer® candidates.

Location: Leiden, NL (on-site).

The Role:

As a (Senior) Research Technician Translational Development, you will contribute to the team’s in-house bioanalytical efforts, in vitro safety studies, and functional biomarker analysis. Your role will involve performing (non-GLP) measurement of oligonucleotide and biomarker concentrations in relevant tissues and matrices, as well as supporting in vitro studies evaluating various safety aspects and (in vitro) PKPD relationships. You will also be responsible for developing and qualifying new methods, optimizing sample preparation protocols, and generating study data. We seek a candidate who can efficiently transition from planning to experimentation and deliver precise results in a timely manner.

We expect our (Senior) Research Technician Translational Development to have:

• To hold a HLO/Bachelor’s degree or Master’s degree in Biology, Biochemistry, Biomedical Sciences, Bio-Pharmaceutical Sciences or a related field with at least 2 years of relevant experience.
• To have experience with HPLC analysis and data processing.
• To have experience with cell culture and immunoassays.
• To be solution- and result-driven.
• To plan and execute experiments effectively.
• To manage laboratory organization and administrative tasks.

Skills and competencies that are required for making the difference:

• Analytical and accurate
• Creative thinker
• Flexible and resistant to change
• Pro-active attitude
• Team-player
• Autonomous and coachable
• Being able to work in a fast-paced environment
• Excellent knowledge of spoken and written English
• A nice person 😊

ProQR as an employer

As an employer, we are a true believer of the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and professionally. We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome things.

We are committed to ensure that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and the contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• 8% holiday allowance
• 30 vacation days
• An annual performance bonus
• Stock options
• A premium-free pension plan
• A commuting allowance
• A subsidized staff restaurant
• Unlimited (un)healthy snacks and drinks
• Employee events (boot camp, Rebel Café and other social events)

Do you think you can contribute to achieving our mission? If so, we’re looking forward to receiving your application by filling out our application form.

You can contact Silvia Catellani via recruitment@proqr.com if you have any questions.